Maximum Likelihood Estimation of Frequencies of Known Haplotypes from Pooled Sequence Data
نویسندگان
چکیده
منابع مشابه
Maximum Likelihood Estimation of Frequencies of Known Haplotypes from Pooled Sequence Data
DNA samples are often pooled, either by experimental design or because the sample itself is a mixture. For example, when population allele frequencies are of primary interest, individual samples may be pooled together to lower the cost of sequencing. Alternatively, the sample itself may be a mixture of multiple species or strains (e.g., bacterial species comprising a microbiome or pathogen stra...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2013
ISSN: 0737-4038,1537-1719
DOI: 10.1093/molbev/mst016